… )-26 with a salt additive (1 M LiCl) and acetic acid additive to enhance enantioselectivity
of the (S)-aminoaldehyde products 27 (Scheme 8). The aminoaldehdye adducts were …

… A 100 mL flask equipped with a stir bar was charged with (S,S)-1 (242 mg, 400 μmol,
0.002 … The reaction was allowed to warm to room temperature and stir 14 h at which time (S)-…

A major challenge in drug discovery is to distinguish the molecular targets of a bioactive
compound from the hundreds to thousands of additional gene products that respond indirectly to …

Chiral BINOL-derived Brønsted acids catalyze the enantioselective asymmetric Morita−Baylis−Hillman
(MBH) reaction of cyclohexenone with aldehydes. The asymmetric MBH reaction …

… The viability of this strategy is illustrated in practical syntheses of (S)-propranolol, a widelyused
anti-hypertensive agent, 9 and (R)-9-[2-(phosphonomethoxy) propyl] adenine (PMPA), a …

… Other chiral diols, such as (S,S)-1,2-diphenylethane diol 2 and (−)-… , (S)-BIPHEN 4 and
(S)-BINOL 5a both gave increases in yield over the uncatalyzed reaction (entries 5 and 6), and (S)-…

… In the asymmetric allylboration of ketones, the (S)-homoallylic alcohol is the major
enantiomer isolated from the reaction catalyzed by (S)-7h (Scheme 4). However, using the same …

… SEM was performed with a low-voltage, high-resolution SEM (Hitachi S-900) at 1.5 keV
with stereo-pair images obtained at ±5.0-degree tilt angles from the horizontal. Stereo pair …

… The first catalytic enantioselective conjugate addition was documented in Wynberg’s [2]
seminal work on Cinchona alkaloid-catalyzed addition of cyclic β-ketoesters to methyl vinyl …

Cinchona alkaloids catalyze the enantioselective Mannich reaction of β-keto esters with
acyl aryl imines. The reaction requires 10 mol % of cinchonine or cinchonidine. The reaction …